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Theophylline
Time:2019-11-11 9:51:40 Hit:308
 

Theophylline is a methylpurine.Have strong heart, diuresis, dilate coronary artery, relax smooth muscle of bronchus and excited central nervous system to wait for action.Mainly used for the treatment of bronchial asthma, emphysema, bronchitis, cardiac dyspnea.

Chinese name: theophylline

Theophylline

Other names: dioxo dimethylpurine, istheobromine, Theolix, Theocin, 1, 3-dimethyxanthine

Main ingredients

Theophylline is alias: dioxy dimethylpurine;1, 3-dimethyl-3, 7-dihydro-1h-purine-2, 6-diketone;1, 3-dimethylxanthine;Theophylline hydrate;The tea base;Theophylline /1, 3-dimethylxanthine;1, 3-dimethylxanthine

Theophylline

1,3-Dimethyl-3, 7-dihydro-1h-purine-2, 6-Dione;1, 3 - dimethyl - xanthin;1 h - Purine - 2, 6 - dione, 3, 7 - dihydro - 1, 3 - dimethyl -;3, 7 - dihydro - 1, 3 - dimethyl - 1 h - purine - 6 - dione.3 h) - dione, 1, 3 - dimethyl - purine - 6 (1 h,6 - dione, 3, 7 - dihydro - 1, 3 - dimethyl - 1 h - Purine - 2;Accurbron;Acet - theocin

The CAS number: 58-55-9

Quality standard: CP

Molecular formula: C7H8N4O2

Molecular weight: 180.16

EINECS no. : 200-385-7

Density: 1.62 g/cm3

Melting point: 270-274

Boiling point :390.1C at 760 mmHg

Flash: 189.7 C

Steam pressure :2.72E-06mmHg at 25C

Storage conditions: 2-8C

Solubility: 0.1 M HCl: Mice

Water solubility: 8.3g /L (20 & ORDM;C)

Content: 99%

Appearance: white crystalline or crystalline powder, odorless, bitter taste.

Solubility: Dissolved in water (1:120), ethanol (1:18), chloroform (1:86), alkali hydroxide, ammonia water, dilute hydrochloric acid and dilute nitric acid, slightly soluble in ether.

Usage: Theophylline is a methyl purine.Have strong heart, diuresis, dilate coronary artery, excited central classics system to wait for action.Treatment of bronchial asthma, emphysema, bronchitis, cardiac dyspnea.

The preparation methods

(1) Theocrine was prepared by the reaction of 1, 3-dimethyl-4-amino-5-formamide ureacil with sodium hydroxide solution at 90-95. The product was recrystallized by hot water and decolorized by activated carbon.

(2) Using ethyl cyanoacetate and dimethyl urea as raw materials, crude products were prepared by condensation, nitrification, reduction, formylation and cyclization, and recrystallized


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